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Notably, in addition to developing highly specific tools, synergistic combination therapies could be designed (7,8,30,32,34,37,49,5557,80,82,126,127,132,166177)

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Paul Talalay and researchers at Johns Hopkins University linked these findings (Prochaska et al., 1992) and identified sulforaphane, isolated from broccoli, as a potent inducer of phase II detoxification enzymes including glutathione-S-transferase (GST) and NAD(P)H oxidoreductase 1 (NQO1) (Zhang et al., 1992)

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Due to the unique position of the sulfhydryl group on the imidazole ring of histidine, ovothiol (Ovothiol-A), isolated from sea urchins, possesses a distinct antioxidant capacity (Madany et al., 2022)